Joseph L. Goldstein, M.D.

Scientists at Janelia work together in multidisciplinary teams to solve challenging biological problems that are difficult to address in other research settings.

Many lab spaces at Janelia feature modular designs and natural light.

Credit: Brad Feinknopf

Occupying 689 wooded acres along the Potomac River, Janelia Farm provides a variety of services and facilities to support its diverse community of scientists and staff—inside and outside the lab.

A view of the Janelia Farm Research Campus at dusk.

Credit: Brad Feinknopf

The Janelia Farm model frees scientists of constraints commonly found in other research environments, providing access to world-class resources and a talented support staff.

Graduate scholar John Tuthill prepares a Drosophila specimen for imaging.

Credit: James Kegley

In addition to our resident scientists and fellows, we offer visiting scientists, graduate, and undergraduate candidates a range of scientific programs.

Graduate scholar Arbora Resulaj (left) and her mentor, Janelia Fellow Dmitry Rinberg (right).

Credit: James Kegley

Janelia Farm regularly hosts scientific meetings, ranging from workshops to intensive, specialized conferences. See what's coming up and visit the archive of past events.

Janelia's large auditorium seats 250 people.

Credit: Matt Staley

Janelia provides outstanding employment opportunities, at all levels.

Credit: James Kegley

Many tools developed in Janelia Farm labs are made freely available to outside researchers, while others are taking shape through collaborations with industry, academia, and government.

A virtual arena for the study of flight in insects.

Credit: James Kegley

Janelia’s sense of community comes from a core belief that people of diverse disciplines and backgrounds can accomplish great things when working with a common purpose.

Research specialist Trevor Wardill (left) and group leader Vivek Jayaraman (right).

Credit: James Kegley

Joseph L. Goldstein, M.D.

Regental Professor and Chairman
Department of Molecular Genetics
University of Texas Southwestern Medical Center at Dallas

Joseph L. Goldstein and his colleague Michael S. Brown have worked together for the last 39 years on the genetics and regulation of cholesterol metabolism. Their discovery of the LDL receptor as the major molecule regulating cholesterol metabolism and its genetic disruption in the human disease familial hypercholesterolemia has been recognized by their receipt of numerous awards, including the Albert D. Lasker Award in Basic Medical Research (1985), Nobel Prize in Physiology or Medicine (1985), and the U.S. National Medal of Science (1988).

More recently, Goldstein and Brown's discovery of the SREBP family of membrane-bound transcription factors and the elucidation of the proteolytic pathway by which the SREBPs become activated to regulate lipid metabolism were recognized by the receipt of the Albany Medical Prize in Biomedical Sciences in 2003. Goldstein is a past president of the American Society for Clinical Investigation (1985-86) and was a member of the Governing Council of the U.S. National Academy of Sciences (1991-94). He was also a Non-Resident Fellow of The Salk Institute (1983-1994) and served as Chairman of the Medical Advisory Board of the Howard Hughes Medical Institute (1995-2002). Currently, Goldstein is a member of the Board of Trustees of The Rockefeller University and the Board of Trustees of the Howard Hughes Medical Institute, and he serves on several scientific advisory boards for academic institutions and biotechnology companies. He is also Chairman of the Albert Lasker Medical Research Awards Jury.