@article {6952,
	title = {Cell-type-based model explaining coexpression patterns of genes in the brain.},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	volume = {111},
	year = {2014},
	month = {2014 Apr 8},
	pages = {5397-402},
	abstract = {<p>Spatial patterns of gene expression in the vertebrate brain are not independent, as pairs of genes can exhibit complex patterns of coexpression. Two genes may be similarly expressed in one region, but differentially expressed in other regions. These correlations have been studied quantitatively, particularly for the Allen Atlas of the adult mouse brain, but their biological meaning remains obscure. We propose a simple model of the coexpression patterns in terms of spatial distributions of underlying cell types and establish its plausibility using independently measured cell-type-specific transcriptomes. The model allows us to predict the spatial distribution of cell types in the mouse brain.</p>
},
	issn = {1091-6490},
	doi = {10.1073/pnas.1312098111},
	author = {Grange, Pascal and Bohland, Jason W and Okaty, Benjamin W and Sugino, Ken and Bokil, Hemant and Nelson, Sacha B and Ng, Lydia and Hawrylycz, Michael and Mitra, Partha P}
}
