@article {6280, title = {The C-value paradox, junk DNA and ENCODE.}, journal = {Current Biology}, volume = {22}, year = {2012}, month = {2012 Nov 6}, pages = {R898-9}, abstract = {

paradox? You might expect more complex organisms to have progressively larger genomes, but eukaryotic genome size fails to correlate well with apparent complexity, and instead varies wildly over more than a 100,000-fold range. Single-celled amoebae have some of the largest genomes, up to 100-fold larger than the human genome. This variation suggested that genomes can contain a substantial fraction of DNA other than for genes and their regulatory sequences. C.A. Thomas Jr dubbed it the {\textquoteleft}C-value paradox{\textquoteright} in 1971.

}, keywords = {Animals, DNA, DNA Transposable Elements, Genetic, Genome, Genome Size, Human, Humans, Intergenic, Models}, issn = {1879-0445}, doi = {10.1016/j.cub.2012.10.002}, author = {Eddy, Sean R.} }