@article {5335,
	title = {Synergistic actions of metabotropic acetylcholine and glutamate receptors on the excitability of hippocampal CA1 pyramidal neurons.},
	journal = {The Journal of Neuroscience: The Official Journal of the Society for Neuroscience},
	volume = {32},
	year = {2012},
	month = {2012 May 2},
	pages = {6081-91},
	abstract = {<p>A variety of neurotransmitters are responsible for regulating neural activity during different behavioral states. Unique responses to combinations of neurotransmitters provide a powerful mechanism by which neural networks could be differentially activated during a broad range of behaviors. Here, we show, using whole-cell recordings in rat hippocampal slices, that group I metabotropic glutamate receptors (mGluRs) and muscarinic acetylcholine receptors (mAChRs) synergistically increase the excitability of hippocampal CA1 pyramidal neurons by converting the post-burst afterhyperpolarization to an afterdepolarization via a rapidly reversible upregulation of Ca(v)2.3 R-type calcium channels. Coactivation of mAChRs and mGluRs also induced a long-lasting enhancement of the responses mediated by each receptor type. These results suggest that cooperative signaling via mAChRs and group I mGluRs could provide a mechanism by which cognitive processes may be modulated by conjoint activation of two separate neurotransmitter systems.</p>
},
	keywords = {Action Potentials, Animals, Calcium Channels, Cation Transport Proteins, Inbred C57BL, Knockout, Male, Metabotropic Glutamate, Mice, Muscarinic, Pyramidal Cells, R-Type, Rats, Receptors, Wistar},
	issn = {1529-2401},
	doi = {10.1523/JNEUROSCI.6519-11.2012},
	author = {Park, Jin-Yong and Spruston, Nelson}
}
