@article {4589,
	title = {Regular spiking and intrinsic bursting pyramidal cells show orthogonal forms of experience-dependent plasticity in layer V of barrel cortex.},
	journal = {Neuron},
	volume = {73},
	year = {2012},
	month = {2012 Jan 26},
	pages = {391-404},
	abstract = {<p>Most functional plasticity studies in the cortex have focused on layers (L) II/III and IV, whereas relatively little is known of LV. Structural measurements of dendritic spines in\&nbsp;vivo suggest some specialization among LV cell subtypes. We therefore studied experience-dependent plasticity in the barrel cortex using intracellular recordings to distinguish regular spiking (RS) and intrinsic bursting (IB) subtypes. Postsynaptic potentials and suprathreshold responses in\&nbsp;vivo revealed a remarkable dichotomy in RS and IB cell plasticity; spared whisker potentiation occurred in IB but not RS cells while deprived whisker depression occurred in RS but not IB cells. Similar RS/IB differences were found in the LII/III to V connections in brain slices. Modeling studies showed that subthreshold changes predicted the suprathreshold changes. These studies demonstrate the major functional partition of plasticity within a single cortical layer and reveal the LII/III to LV connection as a major excitatory locus of cortical plasticity.</p>
},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2011.11.034},
	author = {Jacob, Vincent and Petreanu, Leopoldo and Wright, Nick and Svoboda, Karel and Fox, Kevin}
}
