@article {6779,
	title = {Slow integration leads to persistent action potential firing in distal axons of coupled interneurons.},
	journal = {Nature Neuroscience},
	volume = {14},
	year = {2011},
	month = {2011 Feb},
	pages = {200-7},
	abstract = {<p>The conventional view of neurons is that synaptic inputs are integrated on a timescale of milliseconds to seconds in the dendrites, with action potential initiation occurring in the axon initial segment. We found a much slower form of integration that leads to action potential initiation in the distal axon, well beyond the initial segment. In a subset of rodent hippocampal and neocortical interneurons, hundreds of spikes, evoked over minutes, resulted in persistent firing that lasted for a similar duration. Although axonal action potential firing was required to trigger persistent firing, somatic depolarization was not. In paired recordings, persistent firing was not restricted to the stimulated neuron; it could also be produced in the unstimulated cell. Thus, these interneurons can slowly integrate spiking, share the output across a coupled network of axons and respond with persistent firing even in the absence of input to the soma or dendrites.</p>
},
	keywords = {Action Potentials, Animals, Axons, Cerebral Cortex, Dendrites, Hippocampus, Interneurons, Mice, Nerve Net, Patch-Clamp Techniques, Synapses, Transgenic},
	issn = {1546-1726},
	doi = {10.1038/nn.2728},
	author = {Sheffield, Mark E J and Best, Tyler K and Mensh, Brett D and Kath, William L and Spruston, Nelson}
}
