@article {1098,
	title = {A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells.},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {18},
	year = {2008},
	month = {2008 Nov 15},
	pages = {5864-6},
	abstract = {<p>A derivative of rhodamine 110 has been designed and assessed as a probe for cytochrome P450 activity. This probe is the first to utilize a {\textquoteright}trimethyl lock{\textquoteright} that is triggered by cleavage of an ether bond. In vitro, fluorescence was manifested by the CYP1A1 isozyme with k(cat)/K(M)=8.8x10(3)M(-1)s(-1) and K(M)=0.09microM. In cellulo, the probe revealed the induction of cytochrome P450 activity by the carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin, and its repression by the chemoprotectant resveratrol.</p>
},
	keywords = {Cytochrome P-450 CYP1A1, Cytochrome P-450 Enzyme System, Fluorescent Dyes, Humans, Isoenzymes, Molecular Structure, Prodrugs, Rhodamines, Stilbenes, Structure-Activity Relationship, Tetrachlorodibenzodioxin},
	issn = {1464-3405},
	doi = {10.1016/j.bmcl.2008.06.015},
	author = {Yatzeck, Melissa M and Lavis, Luke D and Chao, Tzu-Yuan and Chandran, Sunil S and Raines, Ronald T}
}
