@article {6858,
	title = {Function of the Drosophila CPEB protein Orb2 in long-term courtship memory.},
	journal = {Nature Neuroscience},
	volume = {10},
	year = {2007},
	month = {2007 Dec 28},
	pages = {1587-93},
	abstract = {<p>Both long-term behavioral memory and synaptic plasticity require protein synthesis, some of which may occur locally at specific synapses. Cytoplasmic polyadenylation element-binding (CPEB) proteins are thought to contribute to the local protein synthesis that underlies long-term changes in synaptic efficacy, but a role has not been established for them in the formation of long-term behavioral memory. We found that the Drosophila melanogaster CPEB protein Orb2 is acutely required for long-term conditioning of male courtship behavior. Deletion of the N-terminal glutamine-rich region of Orb2 resulted in flies that were impaired in their ability to form long-term, but not short-term, memory. Memory was restored by expressing Orb2 selectively in fruitless (fru)-positive gamma neurons of the mushroom bodies and by providing Orb2 function in mushroom bodies only during and shortly after training. Our data thus demonstrate that a CPEB protein is important in long-term memory and map the molecular, spatial and temporal requirements for its function in memory formation.</p>
},
	keywords = {Animal, Animals, Behavior, Computational Biology, Courtship, Drosophila, Drosophila Proteins, Female, Gene Expression, Genetically Modified, Green Fluorescent Proteins, Male, Memory, Memory Disorders, Mushroom Bodies, Neurons, Phylogeny, RNA-Binding Proteins, Sequence Deletion, Time Factors},
	issn = {1097-6256},
	doi = {10.1038/nn1996},
	author = {Keleman, Krystyna and Kr{\"u}ttner, Sebastian and Alenius, Mattias and Dickson, Barry J}
}
