@article {1239,
	title = {Wiring optimization can relate neuronal structure and function.},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	volume = {103},
	year = {2006},
	month = {2006 Mar 21},
	pages = {4723-8},
	abstract = {<p>We pursue the hypothesis that neuronal placement in animals minimizes wiring costs for given functional constraints, as specified by synaptic connectivity. Using a newly compiled version of the Caenorhabditis elegans wiring diagram, we solve for the optimal layout of 279 nonpharyngeal neurons. In the optimal layout, most neurons are located close to their actual positions, suggesting that wiring minimization is an important factor. Yet some neurons exhibit strong deviations from "optimal" position. We propose that biological factors relating to axonal guidance and command neuron functions contribute to these deviations. We capture these factors by proposing a modified wiring cost function.</p>
},
	keywords = {Animals, Caenorhabditis elegans, Models, Neurological, Neurons, Synapses},
	issn = {0027-8424},
	doi = {10.1371/journal.pcbi.1001066},
	author = {Chen, Beth L and Hall, David H and Chklovskii, Dmitri B}
}
