@article {3918,
	title = {Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons.},
	journal = {Neuron},
	volume = {50},
	year = {2006},
	month = {2006 Apr 20},
	pages = {291-307},
	abstract = {<p>Although radial oblique dendrites are a major synaptic input site in CA1 pyramidal neurons, little is known about their integrative properties. We have used multisite two-photon glutamate uncaging to deliver different spatiotemporal input patterns to single branches while simultaneously recording the uncaging-evoked excitatory postsynaptic potentials and local Ca2+ signals. Asynchronous input patterns sum linearly in spite of the spatial clustering and produce Ca2+ signals that are mediated by NMDA receptors (NMDARs). Appropriately timed and sized input patterns ( approximately 20 inputs within approximately 6 ms) produce a supralinear summation due to the initiation of a dendritic spike. The Ca2+ signals associated with synchronous input were larger and mediated by influx through both NMDARs and voltage-gated Ca2+ channels (VGCCs). The oblique spike is a fast Na+ spike whose duration is shaped by the coincident activation of NMDAR, VGCCs, and transient K+ currents. Our results suggest that individual branches can function as single integrative compartments.</p>
},
	keywords = {Animals, Calcium Channels, Dendrites, Excitatory Postsynaptic Potentials, Glutamic Acid, N-Methyl-D-Aspartate, Patch-Clamp Techniques, Pyramidal Cells, Rats, Receptors, Sprague-Dawley, Synapses, Synaptic Transmission},
	issn = {0896-6273},
	doi = {10.1016/j.neuron.2006.03.016},
	author = {Losonczy, Attila and Magee, Jeffrey C}
}
