@article {2188,
	title = {Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes.},
	journal = {Chemistry \& Biology},
	volume = {11},
	year = {2004},
	month = {2004 Sep},
	pages = {1279-91},
	abstract = {<p>Modular synthesis and substrate stereocontrol were combined to furnish 18,000 diverse 1,3-dioxanes whose distribution in chemical space rivals that of a reference set of over 2,000 bioactive small molecules. Library quality was assessed at key synthetic stages, culminating in a detailed postsynthesis analysis of purity, yield, and structural characterizability, and the resynthesis of library subsets that did not meet quality standards. The importance of this analysis-resynthesis process is highlighted by the discovery of new biological probes through organismal and protein binding assays, and by determination of the building block and stereochemical basis for their bioactivity. This evaluation of a portion of the 1,3-dioxane library suggests that many additional probes for chemical genetics will be identified as the entire library becomes biologically annotated.</p>
},
	keywords = {Amines, Animals, Calmodulin, Combinatorial Chemistry Techniques, Dioxanes, Molecular Structure, Stereoisomerism, Surface Plasmon Resonance, Zebrafish},
	issn = {1074-5521},
	doi = {10.1016/j.chembiol.2004.07.012},
	author = {Wong, Jason C and Sternson, Scott M and Louca, Joseph B and Hong, Roger and Schreiber, Stuart L}
}
