@article {2449,
	title = {Developmental architecture of adult-specific lineages in the ventral CNS of Drosophila.},
	journal = {Development},
	volume = {131},
	year = {2004},
	month = {2004 Oct},
	pages = {5167-84},
	abstract = {<p>In Drosophila most thoracic neuroblasts have two neurogenic periods: an initial brief period during embryogenesis and a second prolonged phase during larval growth. This study focuses on the adult-specific neurons that are born primarily during the second phase of neurogenesis. The fasciculated neurites arising from each cluster of adult-specific neurons express the cell-adhesion protein Neurotactin and they make a complex scaffold of neurite bundles within the thoracic neuropils. Using MARCM clones, we identified the 24 lineages that make up the scaffold of a thoracic hemineuromere. Unlike the early-born neurons that are strikingly diverse in both form and function, the adult specific cells in a given lineage are remarkably similar and typically project to only one or two initial targets, which appear to be the bundled neurites from other lineages. Correlated changes in the contacts between the lineages in different segments suggest that these initial contacts have functional significance in terms of future synaptic partners. This paper provides an overall view of the initial connections that eventually lead to the complex connectivity of the bulk of the thoracic neurons.</p>
},
	keywords = {Animals, Central Nervous System, Drosophila, Drosophila Proteins, Larva, Membrane Glycoproteins},
	issn = {0950-1991},
	doi = {10.1242/dev.01371},
	author = {Truman, James W and Schuppe, Hansj{\"u}rgen and Shepherd, David and Williams, Darren W}
}
