@article {1987,
	title = {Presynaptic cyclic nucleotide-gated ion channels modulate neurotransmission in the mammalian olfactory bulb.},
	journal = {Neuron},
	volume = {37},
	year = {2003},
	month = {2003 Feb 20},
	pages = {639-47},
	abstract = {<p>Cyclic nucleotide-gated channels (CNGCs) on the dendritic cilia of olfactory receptor neurons (ORNs) are critical for sensory transduction in the olfactory system. Do CNGCs also play a role in the axons and/or nerve terminals of ORNs? We find that the cyclic nucleotides cAMP and cGMP can both facilitate and depress synaptic transmission between olfactory nerve fibers and their targets in olfactory bulb glomeruli. Cyclic nucleotides increase intracellular Ca(2+) in ORN terminals and enhance spontaneous transmitter release; at higher concentrations, cyclic nucleotides depress evoked transmission by altering olfactory nerve excitability. Cyclic nucleotides have no effect on transmission or nerve excitability, however, in mice lacking olfactory CNGCs. Taken together, our results identify a novel role for presynaptic CNGCs in modulating neurotransmission.</p>
},
	keywords = {Animals, Calcium, Cyclic, Cyclic GMP, Electric Stimulation, Enzyme Inhibitors, Excitatory Postsynaptic Potentials, Forskolin, GABA Agonists, Inbred C57BL, Ion Channel Gating, Ion Channels, Mice, Nucleotides, Olfactory Bulb, Patch-Clamp Techniques, Presynaptic Terminals, Rats, Sprague-Dawley, Synaptic Transmission},
	issn = {0896-6273},
	author = {Murphy, Gabe J and Isaacson, Jeffry S}
}
