@article {3312,
	title = {Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin.},
	journal = {Organic Letters},
	volume = {3},
	year = {2001},
	month = {2001 Dec 27},
	pages = {4239-42},
	abstract = {<p>Seventy-two hundred potential inhibitors of the histone deacetylase (HDAC) enzyme family, based on a 1,3-dioxane diversity structure, were synthesized on polystyrene macrobeads. The compounds were arrayed for biological assays in a "one bead-one stock solution" format. Metal-chelating functional groups were used to direct the 1,3-dioxanes to HDAC enzymes, which are zinc hydrolases. Representative structures from this library were tested for inhibitory activity and the 1,3-dioxane structure was shown to be compatible with HDAC inhibition. [structure: see text]</p>
},
	keywords = {Amino Acid, Amino Acid Sequence, Anti-Bacterial Agents, Enzyme Inhibitors, Histone Deacetylase Inhibitors, Histone Deacetylases, Hydroxamic Acids, Peptides, Sequence Homology, Structure-Activity Relationship},
	issn = {1523-7060},
	author = {Sternson, S M and Wong, J C and Grozinger, C M and Schreiber, S L}
}
