@article {1518,
	title = {Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration.},
	journal = {Science},
	volume = {292},
	year = {2001},
	month = {2001 Apr 27},
	pages = {737-40},
	abstract = {<p>Slit is secreted by cells at the midline of the central nervous system, where it binds to Roundabout (Robo) receptors and functions as a potent repellent. We found that migrating mesodermal cells in vivo respond to Slit as both an attractant and a repellent and that Robo receptors are required for both functions. Mesoderm cells expressing Robo receptors initially migrate away from Slit at the midline. A few hours after migration, these same cells change their behavior and require Robo to extend toward Slit-expressing muscle attachment sites. Thus, Slit functions as a chemoattractant to provide specificity for muscle patterning.</p>
},
	keywords = {Animals, Body Patterning, Cell Fusion, Cell Movement, Confocal, Drosophila, Drosophila Proteins, Embryo, Epidermis, Immunologic, Mesoderm, Microscopy, Muscles, Mutation, Nerve Tissue Proteins, Nonmammalian, Receptors, Signal Transduction, Stem Cells},
	issn = {0036-8075},
	doi = {10.1126/science.1058766},
	author = {Kramer, S G and Kidd, T and Simpson, J H and Goodman, C S}
}
