@article {1187,
	title = {RNase MRP correctly cleaves a novel R loop at the mitochondrial DNA leading-strand origin of replication.},
	journal = {Genes \& Development},
	volume = {11},
	year = {1997},
	month = {1997 Mar},
	pages = {582-92},
	abstract = {<p>The precursor primer RNA for mammalian mitochondrial DNA leading-strand replication remains as a persistent R loop formed during transcription through the mitochondrial DNA control region. We have examined model R loops, which exist in a novel and physiologically accurate preprimer conformation, as potential substrates for mammalian RNase mitochondrial RNA processing (MRP). Mouse RNase MRP accurately cleaves an R loop containing the mouse mitochondrial DNA origin. The multiple cleavage sites on the R-loop substrate match the priming sites observed in vivo, suggesting that RNase MRP alone is capable of generating virtually all of the leading-strand replication primers.</p>
},
	issn = {0890-9369},
	author = {Clayton, D A and Lee, D Y}
}
