@article {961,
	title = {Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death.},
	journal = {Cell},
	volume = {83},
	year = {1995},
	month = {1995 Dec 29},
	pages = {1253-62},
	abstract = {<p>Apoptotic cell death is a mechanism by which organisms eliminate superfluous or harmful cells. Expression of the cell death regulatory protein REAPER (RPR) in the developing Drosophila eye results in a small eye owing to excess cell death. We show that mutations in thread (th) are dominant enhancers of RPR-induced cell death and that th encodes a protein homologous to baculovirus inhibitors of apoptosis (IAPs), which we call Drosophila IAP1 (DIAP1). Overexpression of DIAP1 or a related protein, DIAP2, in the eye suppresses normally occurring cell death as well as death due to overexpression of rpr or head involution defective. IAP death-preventing activity localizes to the N-terminal baculovirus IAP repeats, a motif found in both viral and cellular proteins associated with death prevention.</p>
},
	keywords = {Amino Acid, Amino Acid Sequence, Animals, Apoptosis, Biological Evolution, Chromosome Deletion, Drosophila, Drosophila Proteins, Electron, Enhancer Elements, Eye, Genes, Genetic, Genetic Testing, Humans, Inhibitor of Apoptosis Proteins, Insect, Insect Proteins, Mammals, Microscopy, Molecular Sequence Data, Mutation, Neurons, Nucleic Acid, Peptides, Repetitive Sequences, Scanning, Sequence Homology, Viral Proteins},
	issn = {0092-8674},
	doi = {10.1186/gb-2007-8-7-r145},
	author = {Hay, B A and Wassarman, D A and Rubin, G M}
}
