@article {967,
	title = {Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.},
	journal = {Cell},
	volume = {67},
	year = {1991},
	month = {1991 Nov 15},
	pages = {701-16},
	abstract = {<p>We have conducted a genetic screen for mutations that decrease the effectiveness of signaling by a protein tyrosine kinase, the product of the Drosophila melanogaster sevenless gene. These mutations define seven genes whose wild-type products may be required for signaling by sevenless. Four of the seven genes also appear to be essential for signaling by a second protein tyrosine kinase, the product of the Ellipse gene. The putative products of two of these seven genes have been identified. One encodes a ras protein. The other locus encodes a protein that is homologous to the S. cerevisiae CDC25 protein, an activator of guanine nucleotide exchange by ras proteins. These results suggest that the stimulation of ras protein activity is a key element in the signaling by sevenless and Ellipse and that this stimulation may be achieved by activating the exchange of GTP for bound GDP by the ras protein.</p>
},
	keywords = {Amino Acid Sequence, DNA Mutational Analysis, Drosophila Proteins, Eye Proteins, Genes, GTP-Binding Proteins, Guanine Nucleotide Exchange Factors, Membrane Glycoproteins, Molecular Sequence Data, Photoreceptor Cells, Protein-Tyrosine Kinases, Proteins, Proto-Oncogene Proteins p21(ras), ras Guanine Nucleotide Exchange Factors, Receptor Protein-Tyrosine Kinases, Restriction Mapping, Saccharomyces cerevisiae, Schizosaccharomyces, Sequence Alignment, Signal Transduction, Structure-Activity Relationship},
	issn = {0092-8674},
	doi = {10.1186/gb-2007-8-7-r145},
	author = {Simon, M A and Bowtell, D D and Dodson, G S and Laverty, T R and Rubin, G M}
}
