@article {1148,
	title = {A molecular analysis of transformer, a gene in Drosophila that controls female sexual differentiation.},
	journal = {Cell},
	volume = {48},
	year = {1987},
	month = {1987 Feb},
	pages = {489-99},
	abstract = {<p>The transformer (tra) gene regulates all aspects of somatic sexual differentiation in Drosophila melanogaster females and has no function in males. We have isolated the tra gene as part of a 200 kb chromosomal walk. The 25 kb region around tra contains four genetically identified complementation groups and at least six transcriptional units. Germ-line transformation experiments indicate that a fragment of 2 kb is sufficient to supply tra+ function. Mapping of cDNAs from tra and from the adjacent genes indicates that the tra+ transcription unit is 1.2 kb or less. This transcription unit gives rise to a 1.0 kb RNA that is female-specific and a 1.2 kb RNA that is present in both sexes. tra+ and the gene at the 3{\textquoteright} side overlap slightly in the 3{\textquoteright} ends of their RNA coding sequences. These results suggest that tra+ function is regulated at the level of production of the female-specific tra RNA. The fact that a tra transcript is found in males raises interesting possibilities for how tra expression is controlled.</p>
},
	issn = {0092-8674},
	author = {Baker, B.S. and McKeown, M. and Belote, J.M.}
}
