@article {979,
	title = {The effect of chromosomal position on the expression of the Drosophila xanthine dehydrogenase gene.},
	journal = {Cell},
	volume = {34},
	year = {1983},
	month = {1983 Aug},
	pages = {47-57},
	abstract = {<p>Thirty-six isogenic D. melanogaster strains that differed only in the chromosomal location of a 7.2 or an 8.1 kb DNA segment containing the (autosomal) rosy gene were constructed by P-element-mediated gene transfer. Since the flies were homozygous for a rosy- allele, rosy gene function in these indicated the influence of flanking sequences on gene expression. The tissue distribution of XDH activity in all the strains was normal. Each line exhibited a characteristic level of adult XDH-specific activity. The majority of these values were close to wild-type levels; however, the total variation in specific activity among the lines was nearly fivefold. Thus position effects influence expression of the rosy gene quantitatively but do not detectably alter tissue specificity. X-linked rosy insertions were expressed on average 1.6 times more activity in males than in females. Hence the gene acquires at least partial dosage compensation upon insertion into the X chromosome.</p>
},
	keywords = {Animals, Chromosomes, DNA Transposable Elements, Dosage Compensation, Drosophila melanogaster, Female, Gene Expression Regulation, Genetic, Ketone Oxidoreductases, Tissue Distribution, Transformation, X Chromosome, Xanthine Dehydrogenase},
	issn = {0092-8674},
	doi = {10.1186/gb-2007-8-7-r145},
	author = {Spradling, A C and Rubin, G M}
}
