@article {1145,
	title = {Sex determination in Drosophila melanogaster: analysis of transformer-2 , a sex-transforming locus.},
	journal = {Proceedings of the National Academy of Sciences of the United States of America},
	volume = {79},
	year = {1982},
	month = {1982 Mar},
	pages = {1568-72},
	abstract = {<p>The transformer-2 (tra-2) locus is one of a set of regulatory loci that control sex determination in Drosophila melanogaster. Temperature-shift experiments with temperature-sensitive tra-2 mutants demonstrate that within single cell lineages tra-2+ function is required at several times, and probably continuously, during development for the occurrence of a series of determinative decisions necessary for female sexual differentiation. Analysis of the effects of tra-2 in the genital disc demonstrates that the tra-2+ function is necessary in females both to prevent male sexual differentiation and to permit female differentiation. These and other results support the model that the tra-2+ and tra+ loci act to control the expression of the bifunctional doublesex (dsx) locus.</p>
},
	issn = {0027-8424},
	author = {Baker, B.S. and Belote, J.M.}
}
