@article {45186,
	title = {Large-scale, high-density (up to 512 channels) recording of local circuits in behaving animals.},
	journal = {Journal of Neurophysiology},
	volume = {111},
	year = {2014},
	month = {2014 Mar},
	pages = {1132-49},
	abstract = {<p>Monitoring representative fractions of neurons from multiple brain circuits in behaving animals is necessary for understanding neuronal computation. Here, we describe a system that allows high-channel-count recordings from a small volume of neuronal tissue using a lightweight signal multiplexing headstage that permits free behavior of small rodents. The system integrates multishank, high-density recording silicon probes, ultraflexible interconnects, and a miniaturized microdrive. These improvements allowed for simultaneous recordings of local field potentials and unit activity from hundreds of sites without confining free movements of the animal. The advantages of large-scale recordings are illustrated by determining the electroanatomic boundaries of layers and regions in the hippocampus and neocortex and constructing a circuit diagram of functional connections among neurons in real anatomic space. These methods will allow the investigation of circuit operations and behavior-dependent interregional interactions for testing hypotheses of neural networks and brain function.</p>
},
	issn = {1522-1598},
	doi = {10.1152/jn.00785.2013},
	author = {Berenyi, Antal and Somogyv{\'a}ri, Zolt{\'a}n and Nagy, Anett J and Roux, Lisa and Long, John D and Fujisawa, Shigeyoshi and Stark, Eran and Leonardo, Anthony and Harris, Timothy D and Buzs{\'a}ki, Gy{\"o}rgy}
}
