@article {46664,
	title = {A cellular resolution map of barrel cortex activity during tactile behavior.},
	journal = {Neuron},
	volume = {86},
	year = {2015},
	month = {2015 Apr 21},
	pages = {783-99},
	abstract = {<p>Comprehensive measurement of neural activity remains challenging due to the large numbers of neurons in each brain area. We used volumetric two-photon imaging in mice expressing GCaMP6s and nuclear red fluorescent proteins to sample activity in 75\% of superficial barrel cortex neurons across the relevant cortical columns, approximately 12,000 neurons per animal, during performance of a single whisker object localization task. Task-related activity peaked during object palpation. An encoding model\&nbsp;related activity to behavioral variables. In the column corresponding to the spared whisker, 300 layer (L) 2/3 pyramidal neurons (17\%) each encoded touch and whisker movements. Touch representation declined by half in surrounding columns; whisker movement representation was unchanged. Following the emergence of stereotyped task-related movement, sensory representations showed no measurable plasticity. Touch direction was topographically organized, with distinct organization for passive and active touch. Our work reveals sparse and spatially intermingled representations of multiple tactile features.</p>
},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2015.03.027},
	author = {Peron, Simon P and Freeman, Jeremy and Iyer, Vijay and Guo, Caiying and Svoboda, Karel}
}
