@article {47974,
	title = {Layer 4 fast-spiking interneurons filter thalamocortical signals during active somatosensation.},
	journal = {Nature Neuroscience},
	volume = {19},
	year = {2016},
	month = {2016 Oct 17},
	pages = {1647-57},
	abstract = {<p>We rely on movement to explore the environment, for example, by palpating an object. In somatosensory cortex, activity related to movement of digits or whiskers is suppressed, which could facilitate detection of touch. Movement-related suppression is generally assumed to involve corollary discharges. Here we uncovered a thalamocortical mechanism in which cortical fast-spiking interneurons, driven by sensory input, suppress movement-related activity in layer 4 (L4) excitatory neurons. In mice locating objects with their whiskers, neurons in the ventral posteromedial nucleus (VPM) fired in response to touch and whisker movement. Cortical L4 fast-spiking interneurons inherited these responses from VPM. In contrast, L4 excitatory neurons responded mainly to touch. Optogenetic experiments revealed that fast-spiking interneurons reduced movement-related spiking in excitatory neurons, enhancing selectivity for touch-related information during active tactile sensation. These observations suggest a fundamental computation performed by the thalamocortical circuit to accentuate salient tactile information.</p>
},
	issn = {1546-1726},
	doi = {10.1038/nn.4412},
	author = {Yu, Jianing and Gutnisky, Diego A and Hires, S Andrew and Svoboda, Karel}
}
