@article {48414,
	title = {The emergence of directional selectivity in the visual motion pathway of Drosophila.},
	journal = {Neuron},
	volume = {94},
	year = {2017},
	month = {2017 Apr 05},
	pages = {168-182.e10},
	abstract = {<p>The perception of visual motion is critical for animal navigation, and flies are a prominent model system for exploring this neural computation. In Drosophila, the T4 cells of the medulla are directionally selective and necessary for ON motion behavioral responses. To examine the emergence of directional selectivity, we developed genetic driver lines for the neuron types with the most synapses onto T4 cells. Using calcium imaging, we found that these neuron types are not directionally selective and that selectivity arises in the T4 dendrites. By silencing each input neuron type, we identified which neurons are necessary for T4 directional selectivity and ON motion behavioral responses. We then determined the sign of the connections between these neurons and T4 cells using neuronal photoactivation. Our results indicate a computational architecture for motion detection that is a hybrid of classic theoretical models.</p>
},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2017.03.010},
	author = {Strother, James A and Wu, Shiuan-Tze and Wong, Allan M and Nern, Aljoscha and Rogers, Edward M and Le, Jasmine Q and Rubin, Gerald M and Reiser, Michael B}
}
