@article {48937,
	title = {larvalign: Aligning gene expression patterns from the larval brain of Drosophila melanogaster.},
	journal = {Neuroinformatics},
	volume = {16},
	year = {2018},
	month = {2018 Jan 1},
	pages = {65-80},
	abstract = {<p>The larval brain of the fruit fly Drosophila melanogaster is a small, tractable model system for neuroscience. Genes for fluorescent marker proteins can be expressed in defined, spatially restricted neuron populations. Here, we introduce the methods for 1) generating a standard template of the larval central nervous system (CNS), 2) spatial mapping of expression patterns from different larvae into a reference space defined by the standard template. We provide a manually annotated gold standard that serves for evaluation of the registration framework involved in template generation and mapping. A method for registration quality assessment enables the automatic detection of registration errors, and a semi-automatic registration method allows one to correct registrations, which is a prerequisite for a high-quality, curated database of expression patterns. All computational methods are available within the larvalign software package: https://github.com/larvalign/larvalign/releases/tag/v1.0.</p>
},
	issn = {1559-0089},
	doi = {10.1007/s12021-017-9349-6},
	author = {Muenzing, Sascha E A and Strauch, Martin and Truman, James W and B{\"u}hler, Katja and Thum, Andreas S and Merhof, Dorit}
}
