@article {49059,
	title = {Integrative whole-brain neuroscience in larval zebrafish.},
	journal = {Current Opinion in Neurobiology},
	volume = {50},
	year = {2018},
	month = {2018 Feb 24},
	pages = {136-145},
	abstract = {<p>Due to their small size and transparency, zebrafish larvae are amenable to a range of fluorescence microscopy techniques. With the development of sensitive genetically encoded calcium indicators, this has extended to the whole-brain imaging of neural activity with cellular resolution. This technique has been used to study brain-wide population dynamics accompanying sensory processing and sensorimotor transformations, and has spurred the development of innovative closed-loop behavioral paradigms in which stimulus-response relationships can be studied. More recently, microscopes have been developed that allow whole-brain calcium imaging in freely swimming and behaving larvae. In this review, we highlight the technologies underlying whole-brain functional imaging in zebrafish, provide examples of the sensory and motor processes that have been studied with this technique, and discuss the need to merge data from whole-brain functional imaging studies with neurochemical and anatomical information to develop holistic models of functional neural circuits.</p>
},
	issn = {1873-6882},
	doi = {10.1016/j.conb.2018.02.004},
	author = {Vanwalleghem, Gilles C and Ahrens, Misha B and Scott, Ethan K}
}
