@article {64997,
	title = {Neural circuit basis of aversive odour processing in drosophila from sensory input to descending output.},
	journal = {bioRxiv},
	year = {2018},
	month = {2018 Aug 26},
	abstract = {<p>Evolution has tuned the nervous system of most animals to produce stereotyped behavioural responses to ethologically relevant stimuli. For example, female\&nbsp;<em>Drosophila</em>\&nbsp;avoid laying eggs in the presence of geosmin, an odorant produced by toxic moulds. Using this system, we now identify third order olfactory neurons that are essential for an innate aversive behaviour. Connectomics data place these neurons in the context of a complete synaptic circuit from sensory input to descending output. We find multiple levels of valence-specific convergence, including a novel form of axo-axonic input onto second order neurons conveying another danger signal, the pheromone of parasitoid wasps. However we also observe a massive divergence as geosmin-responsive second order olfactory neurons connect with a diverse array of \~{}75 cell types. Our data suggest a transition from a labelled line organisation in the periphery to one in which olfactory information is mapped onto many different higher order populations with distinct behavioural significance.</p>
},
	doi = {10.1101/394403},
	author = {Paavo Huoviala and Michael-John Dolan and Fiona M. Love and Shahar Frechter and Ruair{\'\i} J.V. Roberts and Zane Mitrevica and Philipp Schlegel and Alexander Shakeel Bates and Yoshinori Aso and Tiago Rodrigues and Hannah Cornwall and Marcus Stensmyr and Davi Bock and Gerald M. Rubin and Marta Costa and Gregory S.X.E. Jefferis}
}
