@article {65246,
	title = {The computation of directional selectivity in the  OFF motion pathway.},
	journal = {eLife},
	volume = {8},
	year = {2019},
	month = {2019 Dec 11},
	abstract = {<p>In flies, the direction of moving ON and OFF features is computed separately. T4 (ON) and T5 (OFF) are the first neurons in their respective pathways to extract a directionally selective response from their non-selective inputs. Our recent study of T4 found that the integration of offset depolarizing and hyperpolarizing inputs is critical for the generation of directional selectivity. However, T5s lack small-field inhibitory inputs, suggesting they may use a different mechanism. Here we used whole-cell recordings of T5 neurons and found a similar receptive field structure: fast depolarization and persistent, spatially offset hyperpolarization. By assaying pairwise interactions of local stimulation across the receptive field, we found no amplifying responses, only suppressive responses to the non-preferred motion direction. We then evaluated passive, biophysical models and found that a model using direct inhibition, but not the removal of excitation, can accurately predict T5 responses to a range of moving stimuli.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.50706},
	author = {Gruntman, Eyal and Romani, Sandro and Reiser, Michael B}
}
