@article {65390,
	title = {Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b..},
	journal = {Science},
	volume = {368},
	year = {2020},
	month = {2020 Apr 17},
	pages = {303-306},
	abstract = {<p>In many reptiles, including the red-eared slider turtle (), sex is determined by ambient temperature during embryogenesis. We previously showed that the epigenetic regulator is elevated at the male-producing temperature and essential to activate the male pathway. In this work, we established a causal link between temperature and transcriptional regulation of We show that signal transducer and activator of transcription 3 (STAT3) is phosphorylated at the warmer, female-producing temperature, binds the locus, and represses transcription, blocking the male pathway. Influx of Ca, a mediator of STAT3 phosphorylation, is elevated at the female temperature and acts as a temperature-sensitive regulator of STAT3 activation.</p>
},
	issn = {1095-9203},
	doi = {10.1126/science.aaz4165},
	author = {Weber, Ceri and Zhou, Yingjie and Lee, Jong Gwan and Looger, Loren L and Qian, Guoying and Ge, Chutian and Capel, Blanche}
}
