@article {65617,
	title = {Membrane potential dynamics underlying context-dependent sensory responses in the hippocampus.},
	journal = {Nature Neuroscience},
	volume = {23},
	year = {2020},
	month = {2020 Jul 1},
	pages = {881-91},
	abstract = {<p>As animals navigate, they must identify features within context. In the mammalian brain, the hippocampus has the ability to separately encode different environmental contexts, even when they share some prominent features. To do so, neurons respond to sensory features in a context-dependent manner; however, it is not known how this encoding emerges. To examine this, we performed electrical recordings in the hippocampus as mice navigated in two distinct virtual environments. In CA1, both synaptic input to single neurons and population activity strongly tracked visual cues in one environment, whereas responses were almost completely absent when the same cue was presented in a second environment. A very similar, highly context-dependent pattern of cue-driven spiking was also observed in CA3. These results indicate that CA1 inherits a complex spatial code from upstream regions, including CA3, that have already computed a context-dependent representation of environmental features.</p>
},
	issn = {1546-1726},
	doi = {10.1038/s41593-020-0646-2},
	author = {Zhao, Xinyu and Wang, Yingxue and Spruston, Nelson and Magee, Jeffrey C}
}
