@article {65720,
	title = {Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala.},
	journal = {eLife},
	volume = {9},
	year = {2020},
	month = {2020 Sep 01},
	abstract = {<p>The basolateral amygdala complex (BLA), extensively connected with both local amygdalar nuclei as well as long-range circuits, is involved in a diverse array of functional roles. Understanding the mechanisms of such functional diversity will be greatly informed by understanding the cell-type-specific landscape of the BLA. Here, beginning with single-cell RNA sequencing, we identified both discrete and graded continuous gene-expression differences within the mouse BLA. Via in situ hybridization, we next mapped this discrete transcriptomic heterogeneity onto a sharp spatial border between the basal and lateral amygdala nuclei, and identified continuous spatial gene-expression gradients within each of these regions. These discrete and continuous spatial transformations of transcriptomic cell-type identity were recapitulated by local morphology as well as long-range connectivity. Thus, BLA excitatory neurons are a highly heterogenous collection of neurons that spatially covary in molecular, cellular, and circuit properties. This heterogeneity likely drives pronounced spatial variation in BLA computation and function.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.59003},
	author = {O{\textquoteright}Leary, Timothy P and Sullivan, Kaitlin E and Wang, Lihua and Clements, Jody and Lemire, Andrew L and Cembrowski, Mark S}
}
