@article {65895,
	title = {An adaptive optics module for deep tissue multiphoton imaging in vivo},
	journal = {Nature Methods},
	year = {2021},
	month = {2021 Oct 04},
	pages = {1259-64},
	abstract = {<p>Understanding complex biological systems requires visualizing structures and processes deep within living organisms. We developed a compact adaptive optics module and incorporated it into two- and three-photon fluorescence microscopes, to measure and correct tissue-induced aberrations. We resolved synaptic structures in deep cortical and subcortical areas of the mouse brain, and demonstrated high-resolution imaging of neuronal structures and somatosensory-evoked calcium responses in the mouse spinal cord at unprecedented depths\&nbsp;<em>in vivo</em>.</p>
},
	doi = {10.1038/s41592-021-01279-0},
	author = {Cristina Rodr{\'\i}guez and Anderson Chen and Jos{\'e} A. Rivera and Manuel A. Mohr and Yajie liang and Wenzhi Sun and Daniel E. Milkie and Thomas G. Bifano and Xiaoke Chen and Na Ji}
}
