@article {67180,
	title = {Acupuncture modulates immunity in sepsis: Toward a science-based protocol.},
	journal = {Autonomic Neuroscience},
	volume = {232},
	year = {2021},
	month = {2021 Feb 27},
	pages = {102793},
	abstract = {<p>Sepsis is a serious medical condition in which immune dysfunction plays a key role. Previous treatments focused on chemotherapy to control immune function; however, a recognized effective compound or treatment has yet to be developed. Recent advances indicate that a neuromodulation approach with nerve stimulation allows developing a therapeutic strategy to control inflammation and improve organ functions in sepsis. As a quick, non-invasive technique of peripheral nerve stimulation, acupuncture has emerged as a promising therapy to provide significant advantages for immunomodulation in acute inflammation. Acupuncture obtains its regulatory effect by activating the somatic-autonomic-immune reflexes, including the somatic-sympathetic-splenic reflex, the somatic-sympathetic-adrenal reflex, the somatic-vagal-splenic reflex and the somatic-vagal-adrenal reflex, which produces a systemic effect. The peripheral nerve stimulation also induces local reflexes such as the somatic-sympathetic-lung-reflex, which then produces local effects. These mechanisms offer scientific guidance to design acupuncture protocols for immunomodulation and inflammation control, leading to an evidence-based comprehensive therapy recommendation.</p>
},
	issn = {1872-7484},
	doi = {10.1016/j.autneu.2021.102793},
	author = {Pan, Wei-Xing and Fan, Arthur Yin and Chen, Shaozong and Alemi, Sarah Faggert}
}
