@article {67263,
	title = {Hunger or thirst state uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making.},
	journal = {Nature Neuroscience},
	volume = {24},
	year = {2021},
	month = {2021 Jul 01},
	pages = {907-912},
	abstract = {<p>Physiological need states direct decision-making toward re-establishing homeostasis. Using a two-alternative forced choice task for mice that models elements of human decisions, we found that varying hunger and thirst states caused need-inappropriate choices, such as food seeking when thirsty. These results show limits on interoceptive knowledge of hunger and thirst states to guide decision-making. Instead, need states were identified after food and water consumption by outcome evaluation, which depended on the medial prefrontal cortex.</p>
},
	issn = {1546-1726},
	doi = {10.1038/s41593-021-00850-4},
	author = {Eiselt, Anne-Kathrin and Chen, Susu and Chen, Jim and Arnold, Jon and Kim, Tahnbee and Pachitariu, Marius and Sternson, Scott M}
}
