@article {68697,
	title = {Identifying determinants of synaptic specificity by integrating connectomes and transcriptomes},
	journal = {bioRxiv},
	year = {2023},
	month = {2023 Apr 04},
	abstract = {<p>How do developing neurons select their synaptic partners? To identify molecules matching synaptic partners, we integrated the synapse-level connectome of neural circuits with the developmental expression patterns and binding specificities of cell adhesion molecules (CAMs) on pre- and postsynaptic neurons. We focused on parallel synaptic pathways in the Drosophila visual system, in which closely related neurons form synapses onto closely related target neurons. We show that the choice of synaptic partners correlates with the matching expression of receptor-ligand pairs of Beat and Side proteins of the immunoglobulin superfamily (IgSF) CAMs. Genetic analysis demonstrates that these proteins determine the choice between alternative synaptic targets. Combining transcriptomes, connectomes, and protein interactome maps provides a framework to uncover the molecular logic of synaptic connectivity.</p>
},
	doi = {10.1101/2023.04.03.534791},
	url = {https://doi.org/10.1101/2023.04.03.534791},
	author = {Juyoun Yoo and Mark Dombrovski and Parmis Mirshahidi and Aljoscha Nern and Samuel A. LoCascio and S. Lawrence Zipursky and Yerbol Z. Kurmangaliyev}
}
