@article {69438,
	title = {Neural Control of Naturalistic Behavior Choices},
	journal = {Annu Rev Neurosci},
	year = {2024},
	month = {2024 May 09},
	abstract = {<p>In the natural world, animals make decisions on an ongoing basis, continuously selecting which action to undertake next. In the lab, however, the neural bases of decision processes have mostly been studied using artificial trial structures. New experimental tools based on the genetic toolkit of model organisms now make it experimentally feasible to monitor and manipulate neural activity in small subsets of neurons during naturalistic behaviors. We thus propose a new approach to investigating decision processes, termed reverse neuroethology. In this approach, experimenters select animal models based on experimental accessibility and then utilize cutting-edge tools such as connectomes and genetically encoded reagents to analyze the flow of information through an animal{\textquoteright}s nervous system during naturalistic choice behaviors. We describe how the reverse neuroethology strategy has been applied to understand the neural underpinnings of innate, rapid decision making, with a focus on defensive behavioral choices in the vinegar fly <em>Drosophila melanogaster</em>.</p>
},
	issn = {1545-4126},
	doi = {10.1146/annurev-neuro-111020-094019},
	author = {Asinof, Samuel K and Card, Gwyneth M}
}
