@article {69915,
	title = {A Salmonella subset exploits erythrophagocytosis to subvert SLC11A1-imposed iron deprivation},
	journal = {Cell Host \& Microbe},
	volume = {33},
	year = {2025},
	month = {2025 May 14},
	pages = {632-642.e4},
	abstract = {<p>Summary Solute carrier family 11 member 1 (SLC11A1) is critical for host resistance to diverse intracellular pathogens. During infection, SLC11A1 limits Salmonella{\textquoteright}s access to iron, zinc, and magnesium, but only magnesium deprivation significantly impairs Salmonella replication. To understand the unexpected minor impact of iron, we determined Salmonella{\textquoteright}s iron access in infected SLC11A1-deficient and normal mice. Using reporter strains and mass spectrometry of Salmonella purified from the spleen, we found that SLC11A1 caused growth-restricting iron deprivation in a subset of Salmonella. Volume electron microscopy revealed that another Salmonella subset circumvented iron restriction by targeting iron-rich endosomes in macrophages degrading red blood cells (erythrophagocytosis). These iron-replete bacteria dominated overall Salmonella growth, masking the effects of the other Salmonella subset{\textquoteright}s iron deprivation. Thus, SLC11A1 effectively sequesters iron, but heterogeneous Salmonella populations partially bypass this nutritional immunity by targeting iron-rich tissue microenvironments.</p>
},
	keywords = {bacterial infection, heterogeneity, iron limitation, iron transport, NRAMP1, nutritional immunity, Slc11A1},
	issn = {1931-3128},
	doi = {https://doi.org/10.1016/j.chom.2025.04.013},
	url = {https://www.sciencedirect.com/science/article/pii/S1931312825001465},
	author = {B{\'e}atrice Roche and Beatrice Claudi and Olivier Cunrath and Christopher K.E. Bleck and Minia Antelo-Varela and Jiagui Li and Dirk Bumann}
}
