@article {70171,
	title = {Design principles of ciliary signaling.},
	journal = {J Cell Sci},
	volume = {138},
	year = {2025},
	month = {2025 Oct 15},
	abstract = {<p>Primary cilia are microtubule-based sensory organelles that have been conserved throughout eukaryotic evolution. As discussed in this Review, a cilium is an elongated and highly specialized structure, and, together with its ability to selectively traffic and concentrate proteins, lipids and second messengers, it creates a signaling environment distinct from the cell body. Ciliary signaling pathways adopt a bow-tie network architecture, in which diverse inputs converge on shared effectors and second messengers before diverging to multiple outputs. Unlike other cellular bow-tie systems, cells exploit ciliary geometry, compartmentalization and infrastructure to enhance sensitivity at multiple scales, from individual molecular reactions to entire signaling pathways. In cilia, integration of the bow-tie network architecture with their specialized structure and unique environment confers robustness and evolvability, which enables cilia to acquire diverse signaling roles. However, this versatility comes with vulnerability - rare mutations that disrupt the features most essential for cilia robustness cause multisystem ciliopathies.</p>
},
	keywords = {Animals, Cilia, Ciliopathies, Humans, Signal Transduction},
	issn = {1477-9137},
	doi = {10.1242/jcs.264325},
	url = {https://doi.org/10.1242/jcs.264325},
	author = {Ott, Carolyn M and Lippincott-Schwartz, Jennifer}
}
