@article {65141,
	title = {A neural circuit arbitrates between persistence and withdrawal in hungry drosophila.},
	journal = {Neuron},
	volume = {104},
	year = {2019},
	month = {2019 Nov 6},
	pages = {544-58},
	abstract = {<p>In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion and fear. How need and motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that hungry flies persistently track a food odor and increase their effort over repeated trials in the absence of reward suggesting that need dominates negative experience. We further show that odor tracking is regulated by two mushroom body output neurons (MBONs) connecting the MB to the lateral horn. These MBONs, together with dopaminergic neurons and Dop1R2 signaling, control behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one of the MBONs, acts as a brake on odor tracking by connecting feeding and olfaction. Together, our data suggest a function for the\&nbsp;MB in internal state-dependent expression of behavior that can be suppressed by external inputs conveying a competing behavioral drive.</p>
},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2019.07.028},
	author = {Sayin, Sercan and De Backer, Jean-Francois and Siju, K P and Wosniack, Marina E and Lewis, Laurence P and Frisch, Lisa-Marie and Gansen, Benedikt and Schlegel, Philipp and Edmondson-Stait, Amelia and Sharifi, Nadiya and Fisher, Corey B and Calle-Schuler, Steven A and Lauritzen, J Scott and Bock, Davi D and Costa, Marta and Jefferis, Gregory S X E and Gjorgjieva, Julijana and Grunwald Kadow, Ilona C}
}
@article {65207,
	title = {A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila.},
	journal = {Neuron},
	year = {2019},
	month = {2019 Aug 09},
	abstract = {<p>In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion and fear. How need and motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that hungry flies persistently track a food odor and increase their effort over repeated trials in the absence of reward suggesting that need dominates negative experience. We further show that odor tracking is regulated by two mushroom body output neurons (MBONs) connecting the MB to the lateral horn. These MBONs, together with dopaminergic neurons and Dop1R2 signaling, control behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one of the MBONs, acts as a brake on odor tracking by connecting feeding and olfaction. Together, our data suggest a function for the\&nbsp;MB in internal state-dependent expression of behavior that can be suppressed by external inputs conveying a competing behavioral drive.</p>
},
	issn = {1097-4199},
	doi = {10.1016/j.neuron.2019.07.028},
	author = {Sayin, Sercan and De Backer, Jean-Francois and Siju, K P and Wosniack, Marina E and Lewis, Laurence P and Frisch, Lisa-Marie and Gansen, Benedikt and Schlegel, Philipp and Edmondson-Stait, Amelia and Sharifi, Nadiya and Fisher, Corey B and Calle-Schuler, Steven A and Lauritzen, J Scott and Bock, Davi D and Costa, Marta and Jefferis, Gregory S X E and Gjorgjieva, Julijana and Grunwald Kadow, Ilona C}
}
