@article {67704,
	title = {Extracellular glutamate and GABA transients at the transition from interictal spiking to seizures},
	journal = {bioRxiv},
	year = {2020},
	month = {2020 Nov 15},
	abstract = {<p>Focal epilepsy is associated with intermittent brief population discharges (interictal spikes), which resemble sentinel spikes that often occur at the onset of seizures. Why interictal spikes self-terminate whilst seizures persist and propagate is incompletely understood. Here we use fluorescent glutamate and GABA sensors in an awake rodent model of neocortical seizures to resolve the spatiotemporal evolution of both neurotransmitters in the extracellular space. Interictal spikes are accompanied by brief glutamate transients which are maximal at the initiation site and rapidly propagate centrifugally. GABA transients last longer than glutamate transients and are maximal ~1.5 mm from the focus where they propagate centripetally. At the transition to seizures, GABA transients are attenuated, whilst glutamate transients increase in spatial extent. The data imply that an annulus of feed-forward GABA release intermittently collapses, allowing seizures to escape from local inhibitory restraint.</p>
},
	doi = {10.1101/2020.11.13.381707},
	author = {Yoshiteru Shimoda and Vincent Magloire and Jonathan S Marvin and Marco Leite and Loren L Looger and Dimitri M Kullmann}
}
