@article {68488,
	title = {Single-synapse ablation and long-term imaging in live C. elegans.},
	journal = {J Neurosci Methods},
	volume = {173},
	year = {2008},
	month = {09/2008},
	pages = {20-6},
	abstract = {<p>Synapses are individually operated, computational units for neural communication. To manipulate physically individual synapses in a living organism, we have developed a laser ablation technique for removing single synapses in live neurons in C. elegans that operates without apparent damage to the axon. As a complementary technique, we applied microfluidic immobilization of C. elegans to facilitate long-term fluorescence imaging and observation of neuronal development. With this technique, we directly demonstrated the existence of competition between developing synapses in the HSNL motor neuron.</p>
},
	keywords = {Animals, Axons, Behavior, Animal, Caenorhabditis elegans, Diagnostic Imaging, Laser Therapy, Microfluidic Analytical Techniques, Movement, Neurons, Synapses, Time Factors},
	issn = {0165-0270},
	doi = {10.1016/j.jneumeth.2008.05.007},
	author = {Allen, Peter B and Sgro, Allyson E and Chao, Daniel L and Doepker, Byron E and Scott Edgar, J and Shen, Kang and Chiu, Daniel T}
}
