@article {65971,
	title = {Characterization of a common progenitor pool of the epicardium and myocardium.},
	journal = {Science},
	year = {2021},
	month = {2021 Jan 07},
	abstract = {<p>The mammalian heart is derived from multiple cell lineages; however, our understanding of when and how the diverse cardiac cell types arise is limited. We mapped the origin of the embryonic mouse heart at single-cell resolution using a combination of transcriptomic, imaging, and genetic lineage labeling approaches. This provided a transcriptional and anatomic definition of cardiac progenitor types. Furthermore, it revealed a cardiac progenitor pool that is anatomically and transcriptionally distinct from currently known cardiac progenitors. Besides contributing to cardiomyocytes, these cells also represent the earliest progenitor of the epicardium, a source of trophic factors and cells during cardiac development and injury. This study provides detailed insights into the formation of early cardiac cell types, with particular relevance to the development of cell-based cardiac regenerative therapies.</p>
},
	issn = {1095-9203},
	doi = {10.1126/science.abb2986},
	author = {Tyser, Richard C V and Ibarra-Soria, Ximena and McDole, Katie and A Jayaram, Satish and Godwin, Jonathan and van den Brand, Teun A H and Miranda, Antonio M A and Scialdone, Antonio and Keller, Philipp J and Marioni, John C and Srinivas, Shankar}
}
@article {4070,
	title = {A computational statistics approach for estimating the spatial range of morphogen gradients.},
	journal = {Development},
	volume = {138},
	year = {2011},
	month = {2011 Nov},
	pages = {4867-74},
	abstract = {<p>A crucial issue in studies of morphogen gradients relates to their range: the distance over which they can act as direct regulators of cell signaling, gene expression and cell differentiation. To address this, we present a straightforward statistical framework that can be used in multiple developmental systems. We illustrate the developed approach by providing a point estimate and confidence interval for the spatial range of the graded distribution of nuclear Dorsal, a transcription factor that controls the dorsoventral pattern of the Drosophila embryo.</p>
},
	issn = {1477-9129},
	doi = {10.1242/dev.071571},
	author = {Kanodia, Jitendra S and Kim, Yoosik and Tomer, Raju and Khan, Zia and Chung, Kwanghun and Storey, John D and Lu, Hang and Keller, Philipp J and Shvartsman, Stansilas Y}
}
