@article {45866,
	title = {Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor signaling.},
	journal = {eLife},
	volume = {3},
	year = {2014},
	month = {2014 Apr 22},
	pages = {e01699},
	abstract = {<p>Axonal branching allows a neuron to connect to several targets, increasing neuronal circuit complexity. While axonal branching is well described, the mechanisms that control it remain largely unknown. We find that in the Drosophila CNS branches develop through a process of excessive growth followed by pruning. In vivo high-resolution live imaging of developing brains as well as loss and gain of function experiments show that activation of Epidermal Growth Factor Receptor (EGFR) is necessary for branch dynamics and the final branching pattern. Live imaging also reveals that intrinsic asymmetry in EGFR localization regulates the balance between dynamic and static filopodia. Elimination of signaling asymmetry by either loss or gain of EGFR function results in reduced dynamics leading to excessive branch formation. In summary, we propose that the dynamic process of axon branch development is mediated by differential local distribution of signaling receptors. DOI: http://dx.doi.org/10.7554/eLife.01699.001.</p>
},
	issn = {2050-084X},
	doi = {10.7554/eLife.01699},
	author = {Zsch{\"a}tzsch, Marlen and Oliva, Carlos and Langen, Marion and De Geest, Natalie and Ozel, Mehmet Neset and Williamson, W Ryan and Lemon, William C and Soldano, Alessia and Munck, Sebastian and Hiesinger, P Robin and Sanchez-Soriano, Natalia and Hassan, Bassem A}
}
@article {5339,
	title = {Transcriptional control of cell fate specification: lessons from the fly retina.},
	journal = {Current Topics in Developmental Biology},
	volume = {98},
	year = {2012},
	month = {2012},
	pages = {259-76},
	abstract = {<p>It is now widely recognized that as cells of developing tissues transition through successive states of decreasing pluripotency into a state of terminal differentiation, they undergo significant changes in their gene expression profiles. Interestingly, these successive states of increasing differentiation are marked by the spatially and temporally restricted expression of sets of transcription factors. Each wave of transcription factors not only signals the arrival of a given stage in cellular differentiation, but it is also necessary for the activation of the next set of transcription factors, creating the appearance of a smooth, directed, and deterministic genetic program of cellular differentiation. Until recently, however, it was largely unknown which genes, besides each other, these transcription factors were activating. Thus, the molecular definition of any given step of differentiation, and how it gave rise to the following step remained unclear. Recent advances in transcriptomics, bioinformatics, and molecular genetics resulted in the identification of numerous transcription factor target genes (TGs). These advances have opened the door to using similar approaches in developmental biology to understand what the transcriptional cascades of cellular differentiation might be. Using the development of the Drosophila eye as a model system, we discuss the role of transcription factors and their TGs in cell fate specification and terminal differentiation.</p>
},
	keywords = {Animals, Cell Lineage, Developmental, Drosophila melanogaster, Gene Expression Regulation, Genetic, Humans, Retina, Signal Transduction, Transcription},
	issn = {1557-8933},
	doi = {10.1016/B978-0-12-386499-4.00010-0},
	author = {Quan, Xiao-jiang and Ramaekers, Ariane and Hassan, Bassem A}
}
