@article {68813,
	title = {Functional Diversity of Glycinergic Commissural Inhibitory Neurons in Larval Zebrafish},
	journal = {Cell Reports},
	volume = {30},
	year = {2020},
	month = {03/2020},
	pages = {3036-3050.e4},
	abstract = {<p>Summary Commissural inhibitory neurons in the spinal cord of aquatic vertebrates coordinate left-right body alternation during swimming. Their developmental origin, however, has been elusive. We investigate this by comparing the anatomy and function of two commissural inhibitory neuron types, dI6dmrt3a and V0d, derived from the pd6 and p0 progenitor domains, respectively. We find that both of these commissural neuron types have monosynaptic, inhibitory connections to neuronal populations active during fictive swimming, supporting their role in providing inhibition to the contralateral side. V0d neurons tend to fire during faster and stronger movements, while dI6dmrt3a neurons tend to fire more consistently during normal fictive swimming. Ablation of dI6dmrt3a neurons leads to an impairment of left-right alternating activity through abnormal co-activation of ventral root neurons on both sides of the spinal cord. Our results suggest that dI6dmrt3a and V0d commissural inhibitory neurons synergistically provide inhibition to the opposite side across different swimming behaviors.</p>
},
	keywords = {commissural inhibitory neurons, dI6~ neurons, glycinergic interneuons, mid cycle inhibition, spinal cord circuit, V0d neurons, Zebrafish},
	issn = {2211-1247},
	doi = {https://doi.org/10.1016/j.celrep.2020.02.015},
	url = {https://www.sciencedirect.com/science/article/pii/S2211124720301698},
	author = {Chie Satou and Takumi Sugioka and Yuto Uemura and Takashi Shimazaki and Pawel Zmarz and Yukiko Kimura and Shin-ichi Higashijima}
}
