@article {69446, title = {Bacteria-organelle communication in physiology and disease}, journal = {J Cell Biol}, volume = {223}, year = {2024}, month = {2024 May 15}, abstract = {

Bacteria, omnipresent in our environment and coexisting within our body, exert dual beneficial and pathogenic influences. These microorganisms engage in intricate interactions with the human body, impacting both human health and disease. Simultaneously, certain organelles within our cells share an evolutionary relationship with bacteria, particularly mitochondria, best known for their energy production role and their dynamic interaction with each other and other organelles. In recent years, communication between bacteria and mitochondria has emerged as a new mechanism for regulating the host{\textquoteright}s physiology and pathology. In this review, we delve into the dynamic communications between bacteria and host mitochondria, shedding light on their collaborative regulation of host immune response, metabolism, aging, and longevity. Additionally, we discuss bacterial interactions with other organelles, including chloroplasts, lysosomes, and the endoplasmic reticulum (ER).

}, keywords = {Animals, Bacteria, Endoplasmic Reticulum, Host-Pathogen Interactions, Humans, Lysosomes, Mitochondria, Organelles}, issn = {1540-8140}, doi = {10.1083/jcb.202310134}, author = {Lee, Yi-Tang and Senturk, Mumine and Guan, Youchen and Wang, Meng C} } @article {68998, title = {Mitochondrial GTP metabolism controls reproductive aging in C.~elegans.}, journal = {Developmental Cell}, year = {2023}, month = {2023 Sep 07}, abstract = {

Healthy mitochondria are critical for reproduction. During aging, both reproductive fitness and mitochondrial homeostasis decline. Mitochondrial metabolism and dynamics are key factors in supporting mitochondrial homeostasis. However, how they are coupled to control reproductive health remains unclear. We report that mitochondrial GTP (mtGTP) metabolism acts through mitochondrial dynamics factors to regulate reproductive aging. We discovered that germline-only inactivation of GTP- but not ATP-specific succinyl-CoA synthetase (SCS) promotes reproductive longevity in Caenorhabditis elegans. We further identified an age-associated increase in mitochondrial clustering surrounding oocyte nuclei, which is attenuated by GTP-specific SCS inactivation. Germline-only induction of mitochondrial fission factors sufficiently promotes mitochondrial dispersion and reproductive longevity. Moreover, we discovered that bacterial inputs affect mtGTP levels and dynamics factors to modulate reproductive aging. These results demonstrate the significance of mtGTP metabolism in regulating oocyte mitochondrial homeostasis and reproductive longevity and identify mitochondrial fission induction as an effective strategy to improve reproductive health.

}, issn = {1878-1551}, doi = {10.1016/j.devcel.2023.08.019}, author = {Lee, Yi-Tang and Savini, Marzia and Chen, Tao and Yang, Jin and Zhao, Qian and Ding, Lang and Gao, Shihong Max and Senturk, Mumine and Sowa, Jessica N and Wang, Jue D and Wang, Meng C} } @article {69103, title = {Mitochondrial GTP metabolism controls reproductive aging in C.~elegans.}, journal = {Developmental Cell}, volume = {58}, year = {2023}, month = {2023 Dec 04}, pages = {2718-2731.e7}, abstract = {

Healthy mitochondria are critical for reproduction. During aging, both reproductive fitness and mitochondrial homeostasis decline. Mitochondrial metabolism and dynamics are key factors in supporting mitochondrial homeostasis. However, how they are coupled to control reproductive health remains unclear. We report that mitochondrial GTP (mtGTP) metabolism acts through mitochondrial dynamics factors to regulate reproductive aging. We discovered that germline-only inactivation of GTP- but not ATP-specific succinyl-CoA synthetase (SCS) promotes reproductive longevity in Caenorhabditis elegans. We further identified an age-associated increase in mitochondrial clustering surrounding oocyte nuclei, which is attenuated by GTP-specific SCS inactivation. Germline-only induction of mitochondrial fission factors sufficiently promotes mitochondrial dispersion and reproductive longevity. Moreover, we discovered that bacterial inputs affect mtGTP levels and dynamics factors to modulate reproductive aging. These results demonstrate the significance of mtGTP metabolism in regulating oocyte mitochondrial homeostasis and reproductive longevity and identify mitochondrial fission induction as an effective strategy to improve reproductive health.

}, keywords = {Aging, Animals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Guanosine Triphosphate, Longevity, Mitochondria, Mitochondrial Dynamics, Reproduction}, issn = {1878-1551}, doi = {10.1016/j.devcel.2023.08.019}, author = {Lee, Yi-Tang and Savini, Marzia and Chen, Tao and Yang, Jin and Zhao, Qian and Ding, Lang and Gao, Shihong Max and Senturk, Mumine and Sowa, Jessica N and Wang, Jue D and Wang, Meng C} }