@article {69256,
	title = {Dendritic voltage imaging maps the biophysical basis of plateau potentials in the hippocampus},
	journal = {bioRxiv},
	year = {2024},
	month = {2024 Mar 7},
	abstract = {<p>Dendrites on neurons integrate synaptic inputs to determine spike timing. Dendrites also convey back-propagating action potentials (bAPs) which interact with synaptic inputs to produce plateau potentials and to mediate synaptic plasticity. The biophysical rules which govern the timing, spatial structures, and ionic character of dendritic excitations are not well understood. We developed molecular, optical, and computational tools to map sub-millisecond voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons under diverse optogenetic and synaptic stimulus patterns, in acute brain slices. We observed history-dependent bAP propagation in distal dendrites, driven by locally generated Na+ spikes (dSpikes). Dendritic depolarization creates a transient window for dSpike propagation, opened by A-type KV channel inactivation, and closed by slow NaV inactivation. Collisions of dSpikes with synaptic inputs triggered calcium channel and N-methyl-D-aspartate receptor (NMDAR)-dependent plateau potentials, with accompanying complex spikes at the soma. This hierarchical ion channel network acts as a spike-rate accelerometer, providing an intuitive picture of how dendritic excitations shape associative plasticity rules.Competing Interest StatementThe authors have declared no competing interest.</p>
},
	doi = {10.1101/2023.06.02.543490},
	url = {https://www.biorxiv.org/content/early/2024/03/07/2023.06.02.543490},
	author = {Pojeong Park and J. David Wong-Campos and Daniel Itkis and Byung Hun Lee and Yitong Qi and Hunter C. Davis and Jonathan B. Grimm and Sarah E. Plutkis and Luke Lavis and Adam Ezra Cohen}
}
