@article {69341,
	title = {Sloppy morphological tuning in identified neurons of the crustacean stomatogastric ganglion},
	journal = {eLife},
	volume = {6},
	year = {2017},
	month = {2017 Feb 8},
	pages = {e22352},
	abstract = {<p>Neuronal physiology depends on a neuron{\textquoteright}s ion channel composition and unique morphology. Variable ion channel compositions can produce similar neuronal physiologies across animals. Less is known regarding the morphological precision required to produce reliable neuronal physiology. Theoretical studies suggest that moraphology is tightly tuned to minimize wiring and conduction delay of synaptic events. We utilize high-resolution confocal microscopy and custom computational tools to characterize the morphologies of four neuron types in the stomatogastric ganglion (STG) of the crab \textitCancer borealis. Macroscopic branching patterns and fine cable properties are variable within and across neuron types. We compare these neuronal structures to synthetic minimal spanning neurite trees constrained by a wiring cost equation and find that STG neurons do not adhere to prevailing hypotheses regarding wiring optimization principles. In this highly modulated and oscillating circuit, neuronal structures appear to be governed by a space-filling mechanism that outweighs the cost of inefficient wiring.</p>
},
	keywords = {cancer borealis, dendritic tree, neuronal morphology, optimization principles, wiring cost},
	issn = {2050-084X},
	doi = {10.7554/eLife.22352},
	url = {https://doi.org/10.7554/eLife.22352},
	author = {Otopalik, Adriane G and Goeritz, Marie L and Sutton, Alexander C and Brookings, Ted and Guerini, Cosmo and Marder, Eve},
	editor = {Calabrese, Ronald L}
}
@article {69342,
	title = {When complex neuronal structures may not matter},
	journal = {eLife},
	volume = {6},
	year = {2017},
	month = {2017 Feb 6},
	pages = {e23508},
	abstract = {<p>Much work has explored animal-to-animal variability and compensation in ion channel expression. Yet, little is known regarding the physiological consequences of morphological variability. We quantify animal-to-animal variability in cable lengths (CV = 0.4) and branching patterns in the Gastric Mill (GM) neuron, an identified neuron type with highly-conserved physiological properties in the crustacean stomatogastric ganglion (STG) of \textitCancer borealis. We examined passive GM electrotonic structure by measuring the amplitudes and apparent reversal potentials (E\textsubscriptrevs) of inhibitory responses evoked with focal glutamate photo-uncaging in the presence of TTX. Apparent E\textsubscriptrevs were relatively invariant across sites (mean CV {\textpm} SD = 0.04 {\textpm} 0.01; 7{\textendash}20 sites in each of 10 neurons), which ranged between 100{\textendash}800 {\textmu}m from the somatic recording site. Thus, GM neurons are remarkably electrotonically compact (estimated λ \&gt; 1.5 mm). Electrotonically compact structures, in consort with graded transmission, provide an elegant solution to observed morphological variability in the STG.</p>
},
	keywords = {electrotonus, morphology, Stomatogastric ganglion, variability, \textitCancer borealis},
	issn = {2050-084X},
	doi = {10.7554/eLife.23508},
	url = {https://doi.org/10.7554/eLife.23508},
	author = {Otopalik, Adriane G and Sutton, Alexander C and Banghart, Matthew and Marder, Eve},
	editor = {Raman, Indira M}
}
