@article {70364,
	title = {Organellar insights in ageing and longevity},
	journal = {Nat Cell Biol},
	year = {2026},
	month = {2026 Apr 17},
	abstract = {<p>Metabolic processes shape ageing and longevity at multiple levels. Emerging evidence shows that many of these processes are orchestrated within and between cellular organelles. Organelles function not only as metabolic reactors but also as signalling hubs, and their coordination plays crucial roles in maintaining cellular homeostasis and promoting organismal fitness. Rather than acting in isolation, organelles engage in dynamic crosstalk through membrane contact sites, metabolite exchange and signalling interplay. In recent years, organelles have been increasingly recognized as critical regulators of ageing and longevity. Here we summarize age-related organellar changes, highlight organelle-mediated intra- and intercellular signalling communication in lifespan and healthspan regulation, and discuss the active roles of organelles in microbiome-host interactions and transgenerational inheritance in regulating longevity. We further outline how longevity-promoting interventions influence organelles, and provide perspectives on how future technological advances may further accelerate progress in this emerging research topic.</p>
},
	issn = {1476-4679},
	doi = {10.1038/s41556-026-01927-7},
	url = {https://doi.org/10.1038/s41556-026-01927-7},
	author = {Mannino, Philip and Park, Mooncheol and Wang, Meng Carla}
}
@article {69546,
	title = {Chemical Induction of Longevity-Promoting Colanic Acid in the Host{\textquoteright}s Microbiota},
	journal = {bioRxiv},
	year = {2024},
	month = {2024 Jul 23},
	abstract = {<p>Microbiota-derived metabolites have emerged as key regulators of longevity. The metabolic activity of the gut microbiota, influenced by dietary components and ingested chemical compounds, profoundly impacts host fitness. While the benefits of dietary prebiotics are well-known, chemically targeting the gut microbiota to enhance host fitness remains largely unexplored. Here, we report a novel chemical approach to induce a pro-longevity bacterial metabolite in the host gut. We discovered that specific Escherichia coli strains overproduce colanic acids (CAs) when exposed to a low dose of cephaloridine, leading to an increased lifespan in host Caenorhabditis elegans. In the mouse gut, oral administration of low-dose cephaloridine induces the transcription of the capsular biosynthesis operon responsible for CA biosynthesis in commensal E. coli, which overcomes the inhibition of CA biosynthesis above 30 degrees C and enables its induction directly from the microbiota. Importantly, low-dose cephaloridine induces CA independently of its antibiotic properties through a previously unknown mechanism mediated by the membrane-bound histidine kinase ZraS. Our work lays the foundation for microbiota-based therapeutics through the chemical modulation of bacterial metabolism and reveals the promising potential of bacteria-targeting drugs in promoting host longevity.</p>
},
	doi = {10.1101/2024.07.23.604802},
	url = {https://www.doi.org/10.1101/2024.07.23.604802},
	author = {Hu, Guo and Cooke, Matthew Brandon and Wen, Alice X and Yu, Xin and Wang, Jin and Herman, Christophe and Wang, Meng Carla}
}
