@article {49232,
	title = {Lineage-guided Notch-dependent gliogenesis by multi-potent progenitors.},
	journal = {Development (Cambridge, England)},
	year = {2018},
	month = {2018 May 15},
	abstract = {<p>Macroglial cells in the central nervous system exhibit regional specialization and carry out region-specific functions. Diverse glial cells arise from specific progenitors in specific spatiotemporal patterns. This raises an interesting possibility that there exist glial precursors with distinct developmental fates, which govern region-specific gliogenesis. Here we mapped the glial progeny produced by the type II neuroblasts, which, like vertebrate radial glia cells, yield both neurons and glia via intermediate neural progenitors (INPs). Distinct type II neuroblasts produce different characteristic sets of glia. A single INP can make both astrocyte-like and ensheathing glia, which co-occupy a relatively restrictive subdomain. Blocking apoptosis uncovers further lineage distinctions in the specification, proliferation, and survival of glial precursors. Both the switch from neurogenesis to gliogenesis and the subsequent glial expansion depend on Notch signaling. Taken together, lineage origins preconfigure the development of individual glial precursors with involvement of serial Notch actions in promoting gliogenesis.</p>
},
	issn = {1477-9129},
	doi = {10.1242/dev.160127},
	author = {Ren, Qingzhong and Awasaki, Takeshi and Wang, Yu-Chun and Huang, Yu-Fen and Lee, Tzumin}
}
@article {6876,
	title = {Drosophila intermediate neural progenitors produce lineage-dependent related series of diverse neurons.},
	journal = {Development},
	volume = {141},
	year = {2014},
	month = {2014 Jan},
	pages = {253-8},
	abstract = {<p>Drosophila type II neuroblasts (NBs), like mammalian neural stem cells, deposit neurons through intermediate neural progenitors (INPs) that can each produce a series of neurons. Both type II NBs and INPs exhibit age-dependent expression of various transcription factors, potentially specifying an array of diverse neurons by combinatorial temporal patterning. Not knowing which mature neurons are made by specific INPs, however, conceals the actual variety of neuron types and limits further molecular studies. Here we mapped neurons derived from specific type II NB lineages and found that sibling INPs produced a morphologically similar but temporally regulated series of distinct neuron types. This suggests a common fate diversification program operating within each INP that is modulated by NB age to generate slightly different sets of diverse neurons based on the INP birth order. Analogous mechanisms might underlie the expansion of neuron diversity via INPs in mammalian brain.</p>
},
	keywords = {Animals, Brain, Cell Lineage, Drosophila, Genetically Modified, Models, Neural Stem Cells, Neurogenesis, Neurological},
	issn = {1477-9129},
	doi = {10.1242/dev.103069},
	author = {Wang, Yu-Chun and Yang, Jacob S and Johnston, Rebecca and Ren, Qingzhong and Lee, Ying-Jou and Luan, Haojiang and Brody, Thomas and Odenwald, Ward F and Lee, Tzumin}
}
